Uterotrophic activity of a "phytoestrogen-free" rat diet.
نویسندگان
چکیده
Coarse Particles and Dust Storm Mortality In a paper titled "Episodes of High Coarse Partide Concentrations Are Not Associated with Increased Mortality," Schwartz et al. (1) concluded that "coarse particles from windblown dust are not associated with mortality risk." The authors seem to have overlooked the medical literature on the health effects of the historic U.S. dust storms of the dust bowl in 1935 (2-4). Brown et al. (2) reported that
منابع مشابه
The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses.
Many commercial laboratory diets have detectable levels of isoflavones (e.g., phytoestrogens such as genistein [GN]) that have weak estrogenic activity both in vitro and in vivo. During validation studies of the uterotrophic bioassay, diet samples from 20 participating laboratories were collected and analyzed for three major phytoestrogens: GN, daidzein (DN), and coumestrol (CM). Soy phytoestro...
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Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated with increased uterine hyperplasia and DNA content. We previously reported that coumestrol gave a typical estradiol-type uterotrophic response in the immature intact rat, yielding incr...
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Laboratory animal diets for studies to determine the endocrine-disrupting potential of chemicals are under scrutiny because they can affect both assay control values and assay sensitivity. Although phytoestrogen content is important, we have previously shown that a phytoestrogen-rich diet and a phytoestrogen-free diet were equally uterotrophic to rats and advanced vaginal opening (VO) when comp...
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Five rodent diets have been evaluated for their possible effect on the sexual development of the rat. Groups of 12 pregnant Alpk rats were fed one of the following combinations of diets during pregnancy and postnatally: RM3/RM1, AIN-76A/AIN-76A, RM3/AIN-76A, Teklad Global 2016 (Global)/Global and Purina 5001/Purina 5001. AIN-76A is phytoestrogen-free while the other diets contained varying amou...
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Administration of the phytoestrogen coumestrol to ovariectomized rats leads to increases in both wet and dry uterine weights in the absence of an increase in uterine DNA content, as reported by Markaverich et al. [Effects of Coumestrol on Estrogen Receptor Function and Uterine Growth in Ovariectomized Rats. Environ Health Perspect 103:574-581 (1995)]. It was not possible to know if the observed...
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عنوان ژورنال:
- Environmental Health Perspectives
دوره 108 شماره
صفحات -
تاریخ انتشار 2000